top of page

Dodecyl Glucose Health and Skin Benefits

Introduction to Dodecyl Glucose


In the world of skincare, there are many ingredients that often go unnoticed, and dodecyl glucose is one such gem. Through a 2017 research study, dodecyl glucose has been revealed to possess a myriad of benefits for the skin, including enhanced permeability and decreased transepidermal water loss (TWL). 

Unveiling the Enhancer: The study's initial evaluation compared dodecyl 6-amino-6-deoxy-α-D-glucopyranoside 5 (Compound 5) with a control group and a positive control, sorbitan monolaurate (Span 20). The results were astounding, as Compound 5 emerged as a promising enhancer, surpassing expectations. It exhibited a remarkable ability to increase the permeation and penetration of substances such as theophylline and the highly hydrophilic antiviral cidofovir into human skin. This heightened delivery potential opens doors for greater efficacy of skincare products.

Interaction with the Skin Barrier: The study indicated that dodecyl glucose interacts directly with the skin barrier, leaving the stratum corneum proteins unaffected. Through infrared spectroscopy of isolated stratum corneum, researchers observed an intriguing phenomenon—while Compound 5 did not impact the proteins, it did cause a decrease in the lipid chain order. This interaction suggests that dodecyl glucose plays a significant role in modulating the skin's barrier function, allowing for enhanced absorption of beneficial ingredients.


Safety and Compatibility: Ensuring the safety of any skincare ingredient is crucial, and dodecyl glucose passes this test with flying colors. The study demonstrated that Compound 5 exhibited acceptable toxicity levels on HaCaT keratinocyte and 3T3 fibroblast cell lines. This provides reassurance to skincare enthusiasts that dodecyl glucose is compatible with the skin, making it a reliable ingredient to consider for a wide range of formulations.


Reversible Action and Moisture Balance: Transepidermal water loss (TWL) is a common concern for maintaining skin health, and the study revealed an exciting aspect of dodecyl glucose. After the enhancer was removed from the skin, transepidermal water loss returned to baseline values. This highlights the reversible nature of dodecyl glucose's interaction with the skin and its ability to support the skin's natural moisture balance.


Dodecyl glucose, a seemingly unassuming ingredient, has emerged as a game-changer in the world of skincare. Through its demonstrated ability to improve skin permeability, modulate the skin barrier, and reduce transepidermal water loss, this enhancer holds tremendous potential for revolutionizing skincare formulations. With its proven safety and compatibility, dodecyl glucose opens new doors for formulators to enhance the efficacy of their products and provide consumers with transformative skincare experiences.


bottom of page